Every Other Day
The Simplest Schedule - Alternate Daily
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The Every Other Day protocol is the simplest microdosing schedule possible: take a microdose one day, rest the next day, and repeat. This creates a consistent 2-day cycle that's incredibly easy to remember and maintain.
This protocol offers more frequent dosing than the Fadiman approach while still providing essential rest days to prevent tolerance. Many users find this rhythm fits naturally into their weekly routine, especially when aligned with work schedules (e.g., dosing Monday-Wednesday-Friday).
While less studied than the Fadiman Protocol, many practitioners report excellent results with this straightforward approach. It's particularly appealing for those who prefer regularity and want to experience benefits more frequently throughout the week.
π Schedule Overview
Dose on day 1, rest on days 2, 2-day cycle
β¨ Benefits
Simple to Follow
Easiest schedule to remember and maintain
Regular Rhythm
Consistent pattern fits naturally into weekly routines
Frequent Benefits
More dosing days than Fadiman protocol
Flexible Alignment
Easy to align with work/school schedules
π‘ Important Considerations
Is this schedule too frequent?
For most people, alternating days provides enough rest to prevent tolerance. If effects diminish, take a longer break or switch to Fadiman.
How to track which day?
Align with weekdays (e.g., dose Mon-Wed-Fri, rest Tue-Thu-Sat-Sun) for easy tracking.
Can I take weekends off?
Absolutely! Many people dose Mon-Wed-Fri and rest on weekends for work-life balance.
π― Best For
Perfect for those who want a simple, easy-to-remember schedule. Ideal for working professionals who dose on specific weekdays (e.g., Mon-Wed-Fri). Great for people who respond well to more frequent dosing but still want built-in rest days.
Recommended Books
Microdosing Psychedelics
Paul Austin (2018)
A hands-on guide to microdosing protocols for LSD, psilocybin, mescaline, and other substances. Covers scheduling, safety, sourcing, and practical applications for creativity, performance, and well-being.
Your Psilocybin Mushroom Companion
Michelle Janikian (2019)
A comprehensive, beginner-friendly guide to psilocybin mushrooms covering everything from planning safe trips and training guides to microdosing protocols and psychedelic therapy. Journalist Michelle Janikian pairs the latest research with practical, step-by-step advice for both newcomers and experienced users, emphasizing harm reduction throughout.
The Psychedelic Handbook
Rick Strassman (2022)
A comprehensive, evidence-based practical guide covering nine psychedelic substance classes β psilocybin, LSD, DMT/ayahuasca, mescaline, ketamine, MDMA, ibogaine, 5-MeO-DMT, and Salvia divinorum β written by the clinical researcher who conducted the first FDA-approved psychedelic study in a generation. Each chapter addresses pharmacology, therapeutic potential, safe use guidelines, microdosing, and recognition of adverse reactions.
Drug, Set, and Setting
Norman E. Zinberg (1984)
The foundational academic text on controlled drug use, written by Harvard psychiatrist Norman Zinberg, which established the theoretical framework that drug outcomes are determined not just by pharmacology ("drug") but equally by the user's mindset ("set") and their social and physical environment ("setting"). This book provided the scientific basis for the harm-reduction approach that now underpins all responsible psychedelic practice, including microdosing protocols.
Microdosing for Health, Healing, and Enhanced Performance
James Fadiman, Jordan Gruber (2025)
The long-awaited follow-up to The Psychedelic Explorer's Guide, written by the man whose name is on the most widely used microdosing protocol. Fadiman and Gruber distil over a decade of self-reports from thousands of microdosers, alongside the latest clinical research, into the most complete book on the practice to date.
The Microdosing Guidebook
C. J. Spotswood (2022)
A hands-on workbook on microdosing written by a psychiatric nurse practitioner with two decades of clinical experience. Spotswood combines a plain-language summary of the research with worksheets, intention-setting exercises and a guided journal for tracking your own protocol.
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