What is it?
1P-LSD (1-propionyl-lysergic acid diethylamide) is a research chemical and prodrug of LSD-25. It was first synthesized in 2015 and quickly became popular in countries where LSD is illegal, as it initially existed in a legal gray area. When ingested, 1P-LSD is metabolized into LSD-25 in the body, producing nearly identical effects.
For microdosing purposes, 1P-LSD offers similar benefits to LSD-25, with users reporting enhanced creativity, focus, and emotional well-being. The typical microdose range is 5-10 micrograms, taken every 3-4 days according to standard protocols.
🚨 Important Warnings
Please read all warnings carefully before use.
As a research chemical, 1P-LSD has less safety data than LSD-25. Quality and purity can vary significantly between sources.
⚠️ Interactions & Combinations
Important information about drug interactions and combinations. Always consult a physician before combining.
Lithium
Dangerous - Life Threatening
Identical to LSD-25 interactions. Lithium and 1P-LSD combination has led to seizures.
Mechanism: Serotonergic potentiation
💊 Dosage Guidelines
Typical dosage ranges from sub-perceptual microdoses to full psychoactive doses
Microdose
10.0 μg
Sub-perceptual
Threshold
20.0 μg
First noticeable effects
Moderate
100.0 μg
Full effects
Strong
250.0 μg
Intense experience
✨ Reported Effects
Mood Enhancement
Improved emotional well-being and reductions in negative mood reported by microdosers
Enhanced Creativity
Increased divergent thinking, originality, and creative flow states
Improved Focus
Greater concentration and ability to sustain attention on tasks
Cognitive Clarity
Sharper mental acuity and improved problem-solving reported at sub-perceptual doses
Energy & Motivation
Mild increase in drive and engagement with activities without stimulant-like side effects
⚠️ Safety Information
Start with very low doses (10–25μg) as potency is comparable to LSD. Avoid if you have a personal or family history of psychosis, schizophrenia, or bipolar disorder. Do not combine with lithium, MAOIs, tramadol, or SSRIs. Legal status varies significantly by country — research your local regulations before obtaining. Long-term safety data is limited.
🔬 Scientific Research
Current research findings and clinical studies.
1P-LSD acts as a prodrug for LSD-25, being hydrolyzed to LSD in the human body.
⚖️ Legal Status
Current legal status in various jurisdictions. Always respect local laws.
| Jurisdiction | Status | Details |
|---|---|---|
|
Most Countries
(2015) |
Controlled Analog
|
Typically falls under analog laws as an LSD derivative. Legal status varies by country. |
👤 Key Figures
Notable figures associated with the research and history of this substance.
Albert Hofmann
Chemist
Discovered LSD, providing the foundation for understanding lysergamide prodrugs like 1P-LSD.
David E. Nichols
Medicinal chemist
Researched lysergamides and psychedelic receptor pharmacology relevant to LSD analogs.
Torsten Passie
Psychiatrist, researcher
Authored clinical reviews and modern research on LSD effects.
Matthias Liechti
Clinical pharmacologist
Conducted contemporary human LSD studies that inform comparisons with prodrugs.
❓ FAQ
Is 1P-LSD safe to microdose?
Long-term safety data for 1P-LSD is very limited. Given its pharmacological similarity to LSD via the prodrug mechanism, its safety profile is expected to be broadly similar. Risks include psychological discomfort, mood instability, and contraindications with certain psychiatric conditions or medications. Always consult a healthcare professional before use.
How long do effects last?
Effects typically begin 45–75 minutes after ingestion, peak at 3–5 hours, and last 8–12 hours total. Residual effects (afterglow or mild perceptual changes) may persist for several hours beyond the main experience.
Is 1P-LSD legal?
1P-LSD's legal status varies by country. It is controlled in the UK (Psychoactive Substances Act 2016), Germany, and several other countries. In some jurisdictions, analogue acts may apply. Legal status changes frequently — always verify current local regulations before purchase or use.
Important Legal Notice
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