What is it?
Salvia divinorum contains salvinorin A - the **only known naturally occurring kappa opioid receptor agonist**. Extremely short duration (5-15 min). Intense dissociation, reality distortion. Mazatec shamanic use for divination/healing. Not suitable for recreational use. Legal in some US states.
🚨 Important Warnings
Please read all warnings carefully before use.
Extremely intense, disorienting. Physical safety risk (falls, injury). Always have sitter. Not recommended for most users.
Sitting/lying position essential. Remove hazards. Complete loss of awareness possible. Never use in public or while standing.
💊 Dosage Guidelines
Typical dosage ranges from sub-perceptual microdoses to full psychoactive doses
Microdose
0.1 mg
Sub-perceptual
✨ Reported Effects
Dissociative Perception
Altered sense of self, space and time through kappa-opioid receptor activation; distinct from serotonergic psychedelics
Deep Introspection
Intense self-reflective states and access to subconscious content, even at low doses
Mood Modulation
Variable mood effects; some users report calmness and emotional insight at sub-threshold doses
Nature Connectedness
Heightened sense of connection to surroundings and nature reported at very low doses
Unpredictable Effects
Effects are highly dose-sensitive and variable; not well-suited for regular microdosing protocols
⚠️ Safety Information
Salvinorin A is extremely potent — effects occur at microgram doses. Not generally recommended for microdosing due to intense dissociative effects even at low doses. Avoid if you have a history of dissociative or psychotic disorders. Never use alone; always have a sober, experienced sitter present.
🔬 Scientific Research
Current research findings and clinical studies.
Unique kappa opioid mechanism. No cross-tolerance with classic psychedelics. Dysphoric rather than euphoric for most users. Research into pain management potential.
⚖️ Legal Status
Current legal status in various jurisdictions. Always respect local laws.
| Jurisdiction | Status | Details |
|---|---|---|
| US Federal |
Not scheduled federally
|
Legal federally. Banned in many states (20+). Legal status varies widely. |
| Australia |
Schedule 9
|
Prohibited substance. |
👤 Key Figures
Notable figures associated with the research and history of this substance.
R. Gordon Wasson
Ethnobotanist
Documented Mazatec Salvia use with María Sabina in 1962.
Alfredo Ortega
Chemist
Isolated and characterized salvinorin A from Salvia divinorum.
Daniel Siebert
Ethnobotanist, researcher
Documented traditional Mazatec use and modern awareness of Salvia divinorum.
Bryan Roth
Pharmacologist
Identified salvinorin A as a potent kappa-opioid receptor agonist.
❓ FAQ
What is salvinorin A and where does it come from?
Salvinorin A is the primary psychoactive compound in Salvia divinorum, a plant native to the cloud forests of Oaxaca, Mexico. It is the most potent naturally occurring hallucinogen, active at inhaled doses of 200–500 mcg — roughly 5,000 times more potent than mescaline by weight.
How does salvinorin A differ from other psychedelics?
Unlike psilocybin, LSD, and DMT, salvinorin A does not activate serotonin receptors. It is a highly selective kappa-opioid receptor (KOR) agonist, producing effects described as intensely dissociative, spatial, and often entirely non-verbal. Many users report temporary loss of awareness of their physical body and surroundings.
How long do the effects last?
When smoked or vaporized, effects begin within 30–60 seconds, peak at 1–5 minutes, and fully resolve within 5–30 minutes — one of the shortest durations of any psychedelic. Traditional oral consumption of Salvia divinorum leaf produces gentler, longer effects of 1–2 hours.
Is microdosing salvinorin A possible?
At sub-threshold doses of approximately 25–75 mcg, some users report subtle mood enhancement, increased sensory awareness, and introspective clarity without psychedelic effects. However, research on salvinorin A microdosing is extremely limited.
What are the main safety considerations?
Short-term risks include disorientation, loss of motor control, and severe psychological distress if unprepared. Physical risks include falls or accidents due to temporary movement impairment. Not recommended for individuals with personal or family history of psychosis. Safe set and setting are essential.
Important Legal Notice
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