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The Stamets Protocol, created by renowned mycologist Paul Stamets, is a unique approach combining psilocybin microdoses with Lion's Mane mushroom and niacin (Vitamin B3). This "stack" is designed to enhance neurogenesis (growth of new neurons) and improve brain connectivity.
The protocol follows a 7-day cycle: dose for 4 consecutive days, then rest for 3 days. The Lion's Mane is believed to promote nerve growth factor (NGF) production, while niacin helps deliver the compounds across the blood-brain barrier through temporary vasodilation (the "niacin flush").
This protocol is more intensive than the Fadiman approach and may produce more pronounced effects. It's particularly popular among those interested in cognitive enhancement, neuroplasticity, and long-term brain health.
π Schedule Overview
Dose on day 1, 2, 3, 4, rest on days 5, 6, 7, 7-day cycle
β¨ Benefits
Enhanced Neuroplasticity
Lion's Mane promotes nerve growth factor (NGF)
Synergistic Stack
Three compounds work together for amplified effects
More Frequent Dosing
4 consecutive days for sustained benefits
Science-Backed
Created by renowned mycologist Paul Stamets
π‘ Important Considerations
What is the Stamets Stack?
Combines psilocybin (microdose), Lion's Mane mushroom (500-1000mg), and niacin/Vitamin B3 (100-200mg).
What is the "niacin flush"?
Temporary skin tingling/redness from niacin. Harmless but can be uncomfortable. Start with lower doses (50-100mg) if concerned.
Do I need all three components?
Psilocybin alone works, but the full stack is designed for maximum neuroplasticity benefits.
Is 4 days too much?
Some people find 4 consecutive days intense. You can modify to 3 days on if needed.
π― Best For
Excellent for experienced microdosers seeking enhanced neuroplasticity and cognitive benefits. Ideal for those interested in combining psilocybin with other nootropics. Best suited for people comfortable with more frequent dosing and willing to take additional supplements (Lion's Mane, Niacin).
π₯ Videos
Recommended Books
How to Change Your Mind
Michael Pollan (2018)
A groundbreaking exploration of the renaissance in psychedelic research. Michael Pollan takes readers on a journey through the history, science, and personal experience of psychedelic substances.
Food of the Gods
Terence McKenna (1992)
McKenna presents a sweeping argument that psychoactive plants β especially psilocybin mushrooms β played a pivotal role in human cognitive evolution, language development, and cultural formation. A provocative blend of ethnobotany, anthropology, and cultural history.
Microdosing Psychedelics
Paul Austin (2018)
A hands-on guide to microdosing protocols for LSD, psilocybin, mescaline, and other substances. Covers scheduling, safety, sourcing, and practical applications for creativity, performance, and well-being.
Your Psilocybin Mushroom Companion
Michelle Janikian (2019)
A comprehensive, beginner-friendly guide to psilocybin mushrooms covering everything from planning safe trips and training guides to microdosing protocols and psychedelic therapy. Journalist Michelle Janikian pairs the latest research with practical, step-by-step advice for both newcomers and experienced users, emphasizing harm reduction throughout.
The Psychedelic Handbook
Rick Strassman (2022)
A comprehensive, evidence-based practical guide covering nine psychedelic substance classes β psilocybin, LSD, DMT/ayahuasca, mescaline, ketamine, MDMA, ibogaine, 5-MeO-DMT, and Salvia divinorum β written by the clinical researcher who conducted the first FDA-approved psychedelic study in a generation. Each chapter addresses pharmacology, therapeutic potential, safe use guidelines, microdosing, and recognition of adverse reactions.
Microdosing for Health, Healing, and Enhanced Performance
James Fadiman, Jordan Gruber (2025)
The long-awaited follow-up to The Psychedelic Explorer's Guide, written by the man whose name is on the most widely used microdosing protocol. Fadiman and Gruber distil over a decade of self-reports from thousands of microdosers, alongside the latest clinical research, into the most complete book on the practice to date.
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