What is it?
1cP-LSD (1-cyclopropionyl-lysergic acid diethylamide) is another LSD prodrug and research chemical that emerged in 2019 after 1P-LSD became controlled in many jurisdictions. Like 1P-LSD, it metabolizes into LSD-25 in the body and produces virtually identical effects.
For microdosing, 1cP-LSD is used interchangeably with LSD-25, typically at doses of 5-10 micrograms. The standard Fadiman protocol (1 day on, 2 days off) applies equally well to this substance.
🚨 Important Warnings
Please read all warnings carefully before use.
Very limited long-term safety data. Purity and dosing accuracy can vary significantly between vendors.
⚠️ Interactions & Combinations
Important information about drug interactions and combinations. Always consult a physician before combining.
Tramadol
Risk of Serotonin Syndrome
Similar to LSD-25, combining with tramadol significantly increases risk of serotonin syndrome.
💊 Dosage Guidelines
Typical dosage ranges from sub-perceptual microdoses to full psychoactive doses
Microdose
10.0 μg
Sub-perceptual
✨ Reported Effects
Mood Enhancement
Improved emotional well-being and positive affect reported at sub-perceptual doses
Enhanced Creativity
Increased divergent thinking and creative output comparable to LSD at equivalent doses
Improved Focus
Enhanced ability to concentrate and maintain attention on tasks
Cognitive Clarity
Sharper mental acuity and clearer thinking without perceptual disruption
Energy & Motivation
Mild increase in motivation and engagement with daily activities
⚠️ Safety Information
Safety profile closely mirrors LSD. Start with very low doses (10–20μg). Avoid if you have a history of psychosis, schizophrenia, or cardiovascular conditions. Do not combine with lithium, tramadol, MAOIs, or SSRIs. Legal status varies significantly between countries — verify local regulations. Long-term safety data is lacking as it is a relatively novel compound.
⚖️ Legal Status
Current legal status in various jurisdictions. Always respect local laws.
| Jurisdiction | Status | Details |
|---|---|---|
|
Germany
(2020) |
Controlled
|
Explicitly scheduled in 2020. Now falls under analog laws in most jurisdictions. |
👤 Key Figures
Notable figures associated with the research and history of this substance.
Albert Hofmann
Chemist
Discovered LSD, providing the foundation for understanding lysergamide prodrugs like 1cP-LSD.
David E. Nichols
Medicinal chemist
Researched lysergamides and psychedelic receptor pharmacology relevant to LSD analogs.
Torsten Passie
Psychiatrist, researcher
Authored clinical reviews and modern research on LSD effects.
Matthias Liechti
Clinical pharmacologist
Conducted contemporary human LSD studies that inform comparisons with prodrugs.
❓ FAQ
What is the difference between 1cP-LSD and LSD?
1cP-LSD is a structural analog of LSD with a cyclopropionyl group at the N1 position. Like 1P-LSD, it is believed to act as a prodrug that converts to LSD in the body. Most users report effects virtually indistinguishable from LSD, though some note a slightly slower onset or milder character compared to 1P-LSD.
Why does 1cP-LSD exist if 1P-LSD already exists?
Research chemical development follows a cycle of creation and regulation. As analogs like 1P-LSD became controlled in various countries, newer analogs such as 1cP-LSD were developed to fill resulting legal gaps. The cyclopropionyl modification creates a structurally distinct compound not explicitly covered by laws targeting 1P-LSD.
Is 1cP-LSD safe to microdose?
Long-term safety data for 1cP-LSD is extremely limited — it is a newer compound than 1P-LSD with less documented use. Based on the prodrug hypothesis and pharmacological similarity to LSD, its general risk profile is expected to mirror LSD. Risks include psychological discomfort, mood instability, and contraindications with certain psychiatric conditions or medications. Always consult a healthcare professional before use.
How long do effects last?
Effects typically begin 45–90 minutes after ingestion, peak at 3–5 hours, and last 8–12 hours total. Residual effects can persist for several hours beyond the main experience.
Is 1cP-LSD legal?
1cP-LSD is a newer compound and its legal status changes frequently as regulators respond to novel psychoactive substances. It may be covered under broad psychoactive substance acts, analogue laws, or specific NPS legislation depending on jurisdiction. Always verify current local regulations before purchase or use.
Important Legal Notice
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