What is it?
Ketamine is a dissociative anesthetic used medically since 1970. **Spravato** (esketamine nasal spray) FDA-approved for treatment-resistant depression (2019) - only legal psychedelic therapy. K-hole at high doses. Bladder toxicity concern with frequent use.
π¨ Important Warnings
Please read all warnings carefully before use.
Frequent use can cause bladder damage (ketamine bladder syndrome). Medical monitoring recommended for regular use.
β οΈ Interactions & Combinations
Important information about drug interactions and combinations. Always consult a physician before combining.
CNS Depressants
Dangerous with alcohol, benzodiazepines, opioids. Respiratory depression risk.
π Microdosing Protocols
Recommended protocols and regimens for microdosing this substance.
Medical Ketamine
Administered IV/IM in clinical settings. 0.5mg/kg typical dose. 6-8 sessions over 2-4 weeks for depression.
π¬ Scientific Research
Current research findings and clinical studies.
Rapid antidepressant effects within hours. 60-70% response rate in treatment-resistant depression. Effects last days to weeks.
βοΈ Legal Status
Current legal status in various jurisdictions. Always respect local laws.
| Jurisdiction | Status | Details |
|---|---|---|
| US |
Schedule III
|
Legal by prescription. Spravato (esketamine) FDA-approved 2019 for treatment-resistant depression. |
π€ Key Figures
Notable figures associated with the research and history of this substance.
Robert Berman
Published first ketamine depression study (2000) showing rapid antidepressant effects.
β οΈ Important Legal Notice
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