Surrender, disidentification, and reappraisal: a qualitative comparison of psilocybin responders and non-responders in treatment-resistant OCD

This qualitative case comparison (n=6) examined three responders and three non-responders after psilocybin (0.25 mg/kg) with psychological support for treatment-resistant OCD. Responders described surrender, self-compassion, emotional engagement and reduced conviction in OCD’s demands; non-responders described persistent control or overwhelming experiences. The purposively selected interviews generate hypotheses about response and cannot establish causal mechanisms or treatment efficacy.