No Heavy Drinking Days and Percentage of Days Abstinent in a Randomized Trial of Adjunctive Ketamine for Alcohol Use Disorder: Secondary Analysis of the KARE Trial

This post hoc preprint reanalysed the KARE alcohol-use-disorder trial (96 randomised; 85 with follow-up diary data). Its main contrast compared ketamine plus mindfulness-based support (n=20) with saline plus psychoeducation (n=23). Across weeks 17–24, days abstinent were 78.5% versus 57.8% (p=.032). The proportion with no heavy drinking days at weeks 21–24 was higher numerically, but not significantly (50.0% versus 26.1%; p=.127). This treatment-package comparison does not isolate ketamine’s effect, and comparisons with other medicines were indirect.