Distinct response of resting-state brain networks to psilocybin in autism

This double-blind, pseudo-randomised crossover brain imaging study (n=67) compared autistic and non-autistic adults after single doses of psilocybin (2 or 5 mg) or placebo. The 5 mg dose altered resting-state brain-network connectivity in different ways, increasing integration between higher-order and attention networks in autistic participants but decreasing it in non-autistic participants.