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Psychedelics News
Curated updates on microdosing, research, policy, and community.
The latest
Tom O’Neill Online Talk
Author of CHAOS The Truth Behind the Manson Murders will be joining us online!
How 'people power' and business transformed medicine, but created a whole new set of risks
There's been a shift in how some medicines and therapeutic products are accessed and used.
Psilocybin providers follow safety guidelines, study finds
A new study has found that Oregon's licensed psilocybin centers largely follow recommended safety guidelines, offering reassurance about how the first regulated psilocybin programs in the U.S. function in practice—tho...
How to Change Your Behavior
A symptom scale can show that someone feels better after a psychedelic experience. Behavior analyst Gianna Biscontini argues that integration should also track what that person does differently on Monday morning.
Anesthesia produces shared neural activity patterns across six species
Anesthetics, drugs that reduce sensation or, in the case of general anesthetics, awareness, help doctors minimize the pain and discomfort experienced by patients during surgeries or other procedures. Many anesthetics ...
Psilocybin Mushrooms Are America’s Psychedelic of Choice
Plus near-death experiences, John Coltrane, and the profound artistry of Pablo Amaringo. [...] Read More...
Investigating molecular and hemodynamic effects of LSD in the human brain
This single-blind PET–MRI study enrolled 11 healthy volunteers receiving LSD (25–200 µg), with seven contributing peak imaging data. LSD occupied 5-HT2A receptors, increased cerebral blood flow and reduced global conn...
Investigating molecular and hemodynamic effects of LSD in the human brain
This single-blind PET–MRI study enrolled 11 healthy volunteers receiving LSD (25–200 µg), with seven contributing peak imaging data. LSD occupied 5-HT2A receptors, increased cerebral blood flow and reduced global conn...
A rodent study found that a PDE9 inhibitor reduced psilocybin-induced head-twitch behaviour and 5-HT2A-related signalling while preserving antidepressant-like responses.
The Neuropsychopharmacology study tested whether boosting cGMP signalling with a phosphodiesterase-9 inhibitor could reduce psilocybin’s perceptual side effects in rodents. The combination also reshaped the synaptic p...
A PET-MRI study in seven healthy volunteers found that LSD increases cerebral blood flow while reducing global brain connectivity, with effects linked to 5-HT2A receptor occupancy.
The Nature Neuroscience study used simultaneous PET-MRI to examine LSD in seven healthy volunteers, finding increased global cerebral and internal carotid artery blood flow alongside reduced global brain connectivity....
LSD microdosing shows potential sustained attention gains in women, but none in men
A pilot study suggests that low doses of LSD may have different effects on sustained attention in women and men. The findings, presented at the ECNP annual congress in Munich, are preliminary, but they add to growing ...
How ‘people power’ and business transformed medicine, but created a whole new set of risks
We’re seeing what happens when consumer demand collides with commercial interests for drugs including GLP-1s, psychedelics and testosterone. It’s a huge shift.
Who Decided Ketamine Was the Future?
This week’s Sunday Insider: Who decided Ketamine was the future…& what would adults choose if they actually got a say in the menu?
A living review of six randomised trials finds MDMA-assisted therapy reduced PTSD symptoms and increased response and remission rates compared with placebo.
The continuously updated synthesis included six randomised controlled trials involving 286 people and provides an open-data meta-analytic platform, including sypres.io. MDMA-assisted therapy showed greater short-term ...
Intensive breathing linked to altered consciousness and brain communication
Intensive breathing exercises can reduce blood flow to the brain by up to 45% and alter communication between brain networks, according to a new brain-imaging study. Participants reported experiences resembling some e...