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Estimating Cardiac 5-HT2B Safety Margins for Repeated Low-Dose Psilocybin Using an Exposure-Response Model
This modelling study, supported by a rat experiment, assessed whether repeated low-dose psilocybin could pose a heart valve risk by acting on the 5-HT2B receptor. It found a 3 mg daily regimen had a large safety margi...
No evidence for deleterious effects of psilocybin and MDMA on working memory or related neurophysiological activity in a non-clinical population: An uncontrolled exploratory study
This uncontrolled exploratory study (n=29 per drug) examined working memory and related brain activity before and after a single dose of psilocybin or MDMA in healthy participants. It found no evidence of lasting work...
What a Healthy Garden Can Teach You About a Psychedelic Trip
12 rules from the soil for your next journey [...] Read More... The post What a Healthy Garden Can Teach You About a Psychedelic Trip appeared first on DoubleBlind Mag.
Magic mushrooms may reshape the brain long after the trip ends
A single dose of psilocybin produced measurable changes in brain activity and possible changes in brain structure that lasted for up to a month. Participants who experienced the greatest increase in flexible, varied b...
Longitudinal neural and psychological changes following psilocybin under compassion imagery priming
This observational study (n=105) examined psilocybin taken after either compassion imagery or breathing-focused priming, using questionnaires and fMRI. It found lasting increases in absorption, decentring and self-com...
Dynamic Substates of the Default Mode Network Are Associated with Mystical Experiences and Clinical Outcomes after Magnesium-Ibogaine Treatment in Veterans with Traumatic Brain Injury
This open-label observational study (n=30) in US veterans with traumatic brain injury (TBI) found that magnesium-ibogaine did not change overall default mode network connectivity, but it did alter a dynamic brain stat...
One of the oldest psychedelics meets modern brain imaging
For millennia, people have used the psychedelic mescaline as a spiritual and religious tool. Mescaline is a naturally occurring chemical found in cacti, mainly peyote cacti, that are located in the Southwest United St...
Psychedelic Disclosures of Being
Review of Phenomenology of Psychedelic Experiences (2025) by Danny Forde
Methking Casino: The Ultimate Review for Players
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Pasithea Therapeutics Announces Presentation of PAS-004 Data to European Society for Medical Oncology (ESMO) Congress 2026
-- Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of PAS-004, a Macrocyclic MEK Inhibitor, for the Treatment of Patients with MAPK Pathway Driven Advanced Solid Tumors will be…
The Vital Conference: Breckenridge 2026
A gathering for the people building the psychedelic field. The Vital Conference brings practitioners, educators, clinicians, facilitators, integration workers, students, and alumni together for two full conference day...
JOURNEYS: A Film Experience + Live Conversation with the Filmmakers
We’re partnering with Psychetheatrics for an online screening of Journeys, Christopher James Cramer’s documentary on psilocybin therapy, followed by a live Zoom conversation with the creative team behind the film. The...