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Psychedelics News
Curated updates on microdosing, research, policy, and community.
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Researchers discover preventative immune benefits of a little-known psychedelic compound
A small study in mice reveals that administering a psychedelic compound before an immune challenge can prevent severe brain inflammation. The findings suggest these drugs might prime the nervous system to resist biolo...
A pilot study at St. Michael’s Hospital found ketamine combined with psychotherapy was feasible and safe for chronic neuropathic pain, with about 80% achieving a meaningful reduction in pain interference by week 20.
Researchers from St. Michael’s Hospital and Unity Health Toronto randomly assigned 30 patients to ketamine infusions, weekly psychotherapy, or both. About 80% of those receiving both treatments improved their pain int...
Pharmacokinetics, pharmacodynamics and safety of-dimethyltryptamine administered intravenously in healthy smoking and non-smoking volunteers
This two-part pharmacokinetic and safety study examined intravenous DMT in healthy smokers and non-smokers using different infusion regimens. Adverse effects were mild to moderate and self-limiting, although two parti...
Pharmacokinetics, pharmacodynamics and safety of-dimethyltryptamine administered intravenously in healthy smoking and non-smoking volunteers
This two-part pharmacokinetic and safety study examined intravenous DMT in healthy smokers and non-smokers using different infusion regimens. Adverse effects were mild to moderate and self-limiting, although two parti...
The Psychedelic Consent Problem
This Week’s Sunday Insider: The Psychedelic industry spends a lot of time debating which drugs are safe…it spends far less time asking whether the people administering them are safe.
A 20-person Johns Hopkins pilot study found supervised psilocybin doses were associated with reduced symptoms of post-treatment Lyme disease, but the uncontrolled findings need confirmation.
Participants received 15 mg and 25 mg doses two weeks apart, with a reported 52% reduction in overall symptom burden two weeks after the second dose and symptoms remaining 40% to 50% below baseline after six months. T...
Magic mushrooms in palliative care: Clinicians are keen but ill-equipped
Once relegated to the counterculture, psilocybin—the psychoactive compound in "magic mushrooms"—has been receiving renewed scientific attention. A growing body of research points to its potential for treating depressi...
A randomized crossover trial comparing the acute physiological and psychological effects of botanical formulations of oral psilocybin, oral psilocin, and sublingual psilocin
This randomised crossover trial (n=20) compared botanical oral psilocybin (25 mg), oral psilocin (17.5 mg), and sublingual psilocin (2.18 to 8 mg) in healthy adults. Oral psilocin produced similar effects to oral psil...
Two low doses of psilocybin reversed depression- and anxiety-like behaviours in chronically stressed rats while restoring brain cell growth and normalising stress hormone levels.
Researchers at the Polish Academy of Sciences found that treated rats resumed normal reward-seeking, explored open areas more, and showed increased neuroplasticity markers in the hippocampus and prefrontal cortex. Cor...
A randomized crossover trial comparing the acute physiological and psychological effects of botanical formulations of oral psilocybin, oral psilocin, and sublingual psilocin
This randomised crossover trial (n=20) compared botanical oral psilocybin (25 mg), oral psilocin (17.5 mg), and sublingual psilocin (2.18 to 8 mg) in healthy adults. Oral psilocin produced similar effects to oral psil...
How might Heidi Overton’s FDA Commissioner nomination shape psychedelics policy? And what is 4-OH-DiPT?
Plus: Can psilocybin therapy move from clinical trials to clinics? And pharmacists argue for a role in psychedelic therapy
Why Psychedelics Make Some Relationships Better (And Others Fall Apart)
The Psychedelic Blog is an independent media brand covering drugs, altered states & the culture surrounding them.
AyaSafe Documents: Seven Free Resources to Enhance the Safety of Ayahuasca Sessions in Non-Native Contexts
ICEERS is making the seven AyaSafe documents publicly available. These documents are part of the Dandelion Model, a proposal for minimum safety standards for facilitators and participants in ayahuasca sessions in non-...
Technodelics Promise Psychedelic Healing. Can They Deliver?
This Santa Monica lab is using mirrors, strobes, and your own goosebumps — no drugs required. [...] Read More... The post Technodelics Promise Psychedelic Healing. Can They Deliver? appeared first on DoubleBlind Mag.
Carlos Castaneda and the addiction to enchantment
I once knew a lady who organized boutique treasure hunts as a side hustle, while doing a PhD in English Literature.