Safety, pharmacokinetics, and pharmacodynamics of intravenously administered deuterated-dimethyltryptamine (CYB004) in healthy volunteers

This randomised, double-blind, placebo-controlled study investigated intravenous CYB004, a deuterated DMT analogue, in healthy volunteers. At clinically relevant exposures, it produced psychedelic, brainwave and autonomic effects similar to DMT, lasted around 40–60 minutes and had an acceptable safety profile, but pharmacokinetic variability remained moderate to high between individuals.