Real-world use, safety, and mental health efficacy of regulated psilocybin services in Oregon and Colorado

This retrospective observational study (n=2363) examined regulated psilocybin services in Oregon and Colorado, where most clients had pre-existing mental health issues. Two weeks after dosing, depression and anxiety scores improved by about half and wellbeing by 22%, but the study also recorded mild adverse events and possible increased suicidality, with limitations including self-reporting and loss to follow-up.