PsyRx reported that ibogaine combined with citalopram produced a statistically significant improvement on one anxiety-related measure in a study of 105 mice.

The preclinical study divided 105 mice into seven groups to assess ibogaine, citalopram and their combination in a depression and anxiety model. Some numerical improvements were seen with low-dose ibogaine plus citalopram, but they were not statistically significant. The findings support further animal research and do not establish efficacy or safety in humans.