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Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors

2026-07-20 β€’ Blossom Pulse: Papers

Article summary

This mouse study examined how psilocybin affects dendrites in the medial frontal cortex and found that it briefly increased calcium activity in apical dendritic tufts only during quiet wakefulness. The effect depended on 5-HT2A receptors, and psilocybin disrupted the usual link between dendritic activity and later spine formation.

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