Pharmacokinetics, pharmacodynamics and safety of-dimethyltryptamine administered intravenously in healthy smoking and non-smoking volunteers

This two-part pharmacokinetic and safety study examined intravenous DMT in healthy smokers and non-smokers using different infusion regimens. Adverse effects were mild to moderate and self-limiting, although two participants stopped after intense effects; smokers had roughly double the blood DMT concentrations of non-smokers, while subjective psychedelic effects were similar between groups.