Participant Experiences of Microdosed Lysergic Acid Diethylamide in a 6-Week Randomised Controlled Trial

This qualitative study (n=40) of healthy males following a double-blind placebo-controlled trial of LSD microdosing (10µg every third day for 6 weeks) found participants reported effects across emotions and mood, social life, mindfulness, cognition and creativity, and physiological domains, with key themes including openness to experiences and bidirectionality of effects, alongside reports of changes in anxiety suggesting important considerations for patient selection and dose optimisation.