Article summary
This reanalysis of a randomised double-blind trial (n=43) compared two low-dose (25 µg) with two higher-dose (100 and 200 µg) LSD treatments in people with major depressive disorder (MDD). Higher-dose LSD increased brain activity during working-memory tasks, and stronger responses were linked to better task performance and more noticeable psychedelic effects, but not to improvements in depressive symptoms.
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