Feasibility and Tolerability of Psilocybin for Phantom Limb Pain

This double-blind, placebo-controlled randomised pilot trial (n=9) assessed the feasibility and tolerability of a single 25-mg dose of psilocybin in people with phantom limb pain after amputation. No serious adverse events or emergent suicidality occurred; pain ratings showed possible reductions after two and four weeks, but these exploratory findings may have been affected by the small sample and unblinding.