Article summary
This double-blind, randomised placebo-controlled trial (n=180 randomised; 173 analysed) found that perioperative esketamine did not improve anxiety response three days after major abdominal tumour surgery: 39.5% versus 42.5% with placebo. Anxiety scores also did not differ significantly at 30 days. Lower depressive symptom scores at 30 days were a secondary finding.
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