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Dynamic Substates of the Default Mode Network Are Associated with Mystical Experiences and Clinical Outcomes after Magnesium-Ibogaine Treatment in Veterans with Traumatic Brain Injury

2026-07-22 β€’ Blossom Pulse: Papers

Article summary

This open-label observational study (n=30) in US veterans with traumatic brain injury (TBI) found that magnesium-ibogaine did not change overall default mode network connectivity, but it did alter a dynamic brain state linked to mystical experiences and clinical improvement one month later. The affected brain pattern was related to a shift towards more internally focused thought.

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