Craving Reduction and Smoking Outcomes in Psilocybin-Assisted and Standard Cessation Care

This observational cohort study (n=115) examined smoking cessation outcomes in people classified as either dependence-predominant or affective-predominant, and found that psilocybin-assisted care was associated with greater smoking reduction at week 12 and larger early reductions in urges, but not with verified abstinence once other factors were accounted for. Early craving reduction was itself associated with abstinence, which was confirmed by exhaled carbon monoxide.