Article summary
This brain imaging study (n=7) used 101 sessions of precision functional mapping to track how psilocybin reshapes brain network organisation over time, finding a sharp acute collapse of the hierarchy separating sensory and higher-order networks followed by a large rebound weeks later, with the connectome settling into a new, more consistent configuration. Long-term changes were unrelated to mystical experience scores, while acute changes were predicted by trait-by-state interactions.
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