Beyond the substance: A systematic review of psychological treatment frameworks in psychedelic-assisted therapy

This systematic review (2026) of 44 clinical trials (1,537 participants) examined psychological treatment frameworks accompanying psilocybin, LSD and DMT for psychiatric symptoms. Most trials used preparation, dosing and integration, but psychological approaches and non-dosing sessions (0–17) varied widely; the authors call for trials that isolate the contribution of psychological components.