A randomized crossover trial comparing the acute physiological and psychological effects of botanical formulations of oral psilocybin, oral psilocin, and sublingual psilocin

This randomised crossover trial (n=20) compared botanical oral psilocybin (25 mg), oral psilocin (17.5 mg), and sublingual psilocin (2.18 to 8 mg) in healthy adults. Oral psilocin produced similar effects to oral psilocybin with fewer adverse effects, while sublingual psilocin was well tolerated but appeared to result in lower drug exposure.