A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers

This randomised, placebo-controlled study (n=48) examining LSD microdosing (15 μg) for analgesia in healthy participants found no significant pain-relieving effects on pain tolerance or subjective pain perception using the Cold Pressor Task. LSD increased blood pressure, which correlated with pain tolerance, and post-hoc analysis in participants without ceiling effects suggested marginal improvements in pain tolerance and reduced unpleasantness only after the first dose, indicating that 15 μg may be below the threshold for consistent analgesic effects.