A living review of six randomised trials finds MDMA-assisted therapy reduced PTSD symptoms and increased response and remission rates compared with placebo.

The continuously updated synthesis included six randomised controlled trials involving 286 people and provides an open-data meta-analytic platform, including sypres.io. MDMA-assisted therapy showed greater short-term symptom reduction, response rates of about 1.35 times higher and remission rates of about 2.25 times higher than control, although overall certainty was rated low.