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Psychedelics News
Curated updates on microdosing, research, policy, and community.
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Mechanisms of anti-depressant and anti- alcohol effects of ketamine in patients with alcohol use disorder
This exploratory preprint reanalysed the KARE trial (n=96 adults with alcohol use disorder), pooling psychological-support conditions to compare three ketamine infusions with saline. Ketamine reduced anhedonia and rep...
Compass Pathways has appointed Kelley Boucher as Chief People Officer, effective immediately, as it scales development of COMP360 psilocybin for psychiatry.
Kelley Boucher joins Compass Pathways as Chief People Officer to support scaling towards bringing COMP360, its proprietary synthetic psilocybin, into psychiatry. The compound is being developed for treatment-resistant...
Alleviating Suicidality by Combining Psychotherapy and IM Ketamine for Rapid Treatment in the Emergency D… (NCT07868913, ketamine)
This Phase II, randomised, quadruple-masked, parallel-group trial (n=200) will evaluate whether intramuscular (IM) ketamine combined with Crisis Response Planning (CRP) rapidly reduces suicidal thoughts in adults aged...
A single dose of MDMA reduced trauma-triggered drinking for up to three weeks in genetically alcohol-prone rats.
In Indiana alcohol-preferring rats, MDMA reduced trauma-triggered drinking, with the strongest effects in animals more vulnerable to drinking and stress sensitivity. The findings suggest altered fear expression rather...
Mechanisms of anti-depressant and anti- alcohol effects of ketamine in patients with alcohol use disorder
This exploratory preprint reanalysed the KARE trial (n=96 adults with alcohol use disorder), pooling psychological-support conditions to compare three ketamine infusions with saline. Ketamine reduced anhedonia and rep...
Statement on DEA attempt to reschedule five tryptamines
Last week, the DEA moved to place five little-known psychedelic compounds — 4-OH-DiPT, 5-MeO-AMT, 5-MeO-MiPT, 5-MeO-DET, and DiPT — into Schedule I of the Controlled Substances Act. It’s the agency’s second attempt at...
Reduced egocentricity after psilocybin in patients with alcohol use disorder: a pilot randomized controlled trial
This preprint reports a secondary visual perspective-taking analysis from a double-blind randomised pilot in recently detoxified people with severe alcohol use disorder and depressive symptoms, with 24 of 30 trial par...
Reduced egocentricity after psilocybin in patients with alcohol use disorder: a pilot randomized controlled trial
This preprint reports a secondary visual perspective-taking analysis from a double-blind randomised pilot in recently detoxified people with severe alcohol use disorder and depressive symptoms, with 24 of 30 trial par...
Definium Therapeutics Announces New Employee Inducement Grants
NEW YORK, September 28, 2026--Definium Therapeutics, Inc. ("Definium" or the "Company"), a late-stage clinical biopharmaceutical company developing a new generation of therapeutics intended to…
Psychedelics reduce bottom-up brain activity in the default mode network
By mapping brain activity like a moving weather system, researchers found that psychedelics consistently reduce the upward flow of sensory information into higher-order brain regions, offering new biological clues int...
The DEA Is Trying to Add a Grip of New Drugs to Schedule I
PLUS LSD art, the recent FDA hearing, and fun games to play while tripping. [...] Read More...
The acid trip in Turn Left at Venus
by Inez Baranay Turn Left at Venus is a novel published in 2019 by Transit Lounge.What follows is a section of the chapter “were we the dead?” which describes an acid trip experienced by the main character, Ada, then ...
Spiral brain dynamics track the temporal unfolding of subjective intensity during the N,N-dimethyltryptamine experience
This preprint reanalysed placebo-controlled DMT fMRI data from healthy volunteers (n=17 for the main analyses; n=14 for time-resolved analyses). DMT increased spiral vorticity and its spatial dispersion and reduced te...
No Heavy Drinking Days and Percentage of Days Abstinent in a Randomized Trial of Adjunctive Ketamine for Alcohol Use Disorder: Secondary Analysis of the KARE Trial
This post hoc preprint reanalysed the KARE alcohol-use-disorder trial (96 randomised; 85 with follow-up diary data). Its main contrast compared ketamine plus mindfulness-based support (n=20) with saline plus psychoedu...
No Heavy Drinking Days and Percentage of Days Abstinent in a Randomized Trial of Adjunctive Ketamine for Alcohol Use Disorder: Secondary Analysis of the KARE Trial
This post hoc preprint reanalysed the KARE alcohol-use-disorder trial (96 randomised; 85 with follow-up diary data). Its main contrast compared ketamine plus mindfulness-based support (n=20) with saline plus psychoedu...